ABSTRACT
Sulindac has been introduced in suspension dosage form which has suited its low aqueous solubility, its use in the fields of pediatrics and geriatrics, and its requirement of dose flexibility. A wettability study showed that 0.05% tween 20 was the wetting agent of choice. Controlled flocculation was adopted to prepare the flocculated suspensions. 32 deflocculated as well as 20 flocculated suspension formulations were prepared using different classes of suspending agents. The parameters used for evaluation were the sedimentation volume ratio [Vu/Vo], easiness of sediment redispersibility, clarity and color of supernatant, the time of the suspension has remained dispersed after being shaken, degree of flocculation, pH stability, conductivity, specific gravity, rheological properties, and dissolution. The deflocculated formula of choice was formula 18 containing 0.5% xanthan gum. The best flocculated suspension was formula 19 containing 10% glycerin, 10% propylene glycol, and 40% sorbitol as density modifiers